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WHOLE ANIMAL TESTING
WHOLE ANIMAL TESTING
The Animal Phenotyping and Functionality Core recommends designing and executing whole animal and muscle phenotyping studies based on the Standard Operating Procedures published by the TREAT NMD Group for studying mouse models of neuromuscular disease. These protocols are validated and well accepted in the field for phenotyping and standardizing preclinical testing. Modest deviations to the protocols may be required to accommodate some of the differences in equipment within the core. Please consult the core directors regarding any training/consultation for how the cores equipment is used and any required deviations to these SOPs.
Use of treadmill and wheel exercise for impact on mdx mice phenotype
Use of grip strength meter to assess the limb strength of mdx mice
The use of hanging wire tests to monitor muscle strength and condition over time
Behavioural and Locomotor Measurements Using Open Field Animal Activity Monitoring System
Use of treadmill and wheel exercise to assess dystrophic state
BONE TESTING
BONE TESTING
Whole femur bending tests
Mouse 4 point bending protocol. This protocol was written for use with a custom testing frame used on an MTS mini-bionix system.
Four point bending for human long bones. This protocol was designed for use with custom fixtures on an Instron testing frame.
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