Sixth Annual Musculoskeletal Health Symposium

Building a Stronger Community

May 17, 2022

9:00am - 4:00pm

D. Dan and Betty Kahn Auditorium and Atrium

A. Alfred Taubman Biomedical Science Research Building

External Advisors:

Karyn Esser, PhDLouis C. Gerstenfeld, PhDClifford J. Rosen, MD

Keynote Speakers:

Stephen Parker, PhD and Kayvan Najarian, PhD

Computational Medicine & Bioinformatics, University of Michigan

The 6th Annual Musculoskeletal Health Symposium was held on Tuesday, May 17, 2022 in the Biomedical Science Research Building, BSRB with a remote viewing option. In addition to the keynote presentation the symposium featured a poster session highlighting work by junior faculty, trainees, students, fellows, staff, and house officers. Trainees (students, fellows, house officers) were eligible to compete for 1 of 3 travel awards ($650/award). Awardees were selected as follows: abstracts designated for the poster competition were judged and 6 finalists selected to give short podium presentations at the Symposium. Of these, 3 were selected for travel awards announced at the end of the meeting.

We were very excited about the opportunity for our community coming together for this event to celebrate the incredible MSK research being conducted at UM and our collaborative institutions.

Thank you to all (inside or outside UofM) that were able to attend.

Agenda (Eastern Times): The full agenda as well the Poster Abstract book are available for downloading.

900-915 Welcome and MiMHC Update Karl J. Jepsen, PhD

915-1045 Travel Award Competition Renny Franceschi, PhD, Moderator

Benjamin Yang, “Three-dimensional chromatin re-organization during muscle stem cell aging”

Lena Batoon, PhD, “Macrophage efferocytosis of apoptotic osteoblasts induces bone formation”

Lindsey Lammlin, “CXCL16 Mediates Cell Type-Specific Inflammatory Signaling in Post-Traumatic Osteoarthritis”

Maiko Omi, DDS PhD, “Direct interaction between osteoclasts and osteoblasts induces cell death of osteoblasts at the beginning of bone remodeling cycle to clean-up the bone surface”

Shawn Hallett, “Unraveling diverse functions of PTHrP-expressing chondrocytes in endochondral bones”

Shuqun Qi, PhD, “Autophagy promotes bone formation by mediating lipid catabolism and optimizing energy metabolism to support mTORC1 activity”

1045-1100 Break

1100-1230 Keynote Addresses Karl J. Jepsen, PhD, Moderator

Stephen Parker, PhD “Integrative analysis of single-nucleus multi-omics data across hundreds of skeletal muscle samples reveals context-specific biology

Kayvan Najarian, PhD “Image processing and machine learning for quantitative and automated analysis of biomedical data”

1230-200 Poster Session BSRB Lobby and Rooms ABC

1230-200 Lunch BSRB Rooms ABC

200-300 MiMHC Faculty Presentations Susan Brooks, PhD, Moderator

Lauren Sparks, PhD, Comprehensive interrogation of human skeletal muscle reveals a dissociation between insulin resistance and mitochondrial capacity

Lucia Cevidanes, DDS PhD Clinical decision support system for osteoarthritis of the temporomandibular joint

Tristan Maerz, PhD, 2021 Pilot Grant Awardee Targeting pathological Wnt/β-catenin signaling in post-traumatic osteoarthritis

Ken Kozloff, PhD - 2021 Pilot Grant Awardee Exploration of modulators of responsiveness to anabolic bone signals in osteogenesis imperfecta

300-315 Award Presentation & Conclusion – Renny Franceschi, PhD